Free Kappa Light Chains Urine

The test measures the levels of specific types of free light chains known as kappa and lambda and also the ratio between the two.

Free kappa light chains urine.

What are light chains. 0 26 to 1 65 ratio of kappa lambda. A free light chains test measures the amount of lambda and kappa free light chains in the blood. Please provide service area information to confirm test code for the lab that services your account or to find available tests you can order.

Therefore the serum free light chain test is a better predictor of outcome than the amount of m protein in the blood. If a patient has kappa myeloma their doctor will watch for a rise in the kappa numbers. There are two types of light chains. This can be measured by the free light chain assay test on a blood specimen.

The results of urine kappa and lambda free light chains must be interpreted in conjunction with urine immunofixation. 3 3 to 19 4 mg l kappa free light chains. Results of urine free light chain testing can be used to monitor disease progression or response to therapy in patients for whom urine electrophoresis is unable to provide reliable bence jones protein quantification. While the molecular weight of both light chains is approximately 22 5 kilodaltons in serum κ free light chain κ flc exists primarily as a monomer and λ free light chain λ flc as a covalently linked dimer with a molecular weight of approximately 45 kilodaltons.

In 24 hour specimens a greater than 90 increase in concentration suggests progression or relapse. These unlinked chains are known as free light chains. 5 71 to 26 3 mg l lambda free light chains. If the amount of free light chains is higher or lower than normal it can mean you have a disorder of the plasma cells.

A kappa lambda k l ratio greater than 6 2 suggests the presence of monoclonal kappa light chains. There are two types of light chains. San juan capistrano ca. In general the higher the free light chains the more aggressive the disease is.

A k l ratio less than 0 7 suggests the presence of monoclonal lambda light chains. Normal test results for free light chains are.