Free Lambda Light Chain Monoclonal Protein

Kappa k or lambda l light chain.

Free lambda light chain monoclonal protein.

Each light chain is composed of two tandem immunoglobulin domains. The most common biclonal gammopathy was igg kappa igg lambda followed by igg kappa igm lambda. Monoclonal gammopathy of undetermined significance mgus is a condition in which an abnormal protein known as monoclonal protein or m protein is in your blood. Ife is also more sensitive than pel for detecting small abnormalities that may be present in diseases such as light chain multiple myeloma oligosecretory myeloma and plasmacytomas.

If the amount of free light chains is higher or lower than normal it can mean you have a disorder of the plasma cells. Serum free light chain testing provides complementary information to the two protein electrophoresis tests. This procedure tells you whether there is a monoclonal protein present. This can be measured by the free light chain assay test on a blood specimen.

You also do this procedure using urine because sometimes myeloma cells will only make light chains which end up being peed out in the urine so if you only did a spep you would miss. Also called kappa and lambda light chains they link together with other proteins heavy chains to form immunoglobulins also known as antibodies that target and neutralize specific threats to the body such as bacteria and viruses. This abnormal protein is formed within your bone marrow the soft blood producing tissue that fills in the center of most of your bones. The first thing that s usually done in the lab is serum protein electophoresis spep.

When myeloma progresses the myeloma cells start to produce more light chains than heavy chains. High levels of igm suggest you may have waldenstrom s macroglobulinemia. It can also detect changes in the ratio of kappa and lambda light chain production which indicates an excess of abnormal plasma cells. One constant c l domain.

The sflc assay can detect abnormal levels of free light chains which may be an indication of a plasma cell disorder. Heavy chains and light chains. Ife characterizes the type of monoclonal protein gamma alpha mu delta or epsilon heavy chain. A free light chains test measures the amount of lambda and kappa free light chains in the blood.

The approximate length of a light chain protein is from 211 to 217 amino acids. Igd myeloma is rare representing 1 of all myeloma cases. This is called a monoclonal protein also called m protein or m spike. One variable domain v l that is important for binding antigen.

In our series igg lambda was the most common monoclonal protein accompanied by excess free light chains. There are two types of light chains called kappa and lambda. The most common type of m protein in myeloma is igg. The constant region determines what class kappa or lambda the light chain is.

Biclonal gammopathies have the same clinical findings as monoclonal gammopathies. Light chains are proteins produced by immune cells called plasma cells.